Immediately after a long period of mourning, Izzie moved on but declined Alex’s offer out-of a relationship

Whenever Meredith needed emails on her demo, Alex named Izzie, and in their dialogue she showed that she got provided birth to help you twins, playing with a suspended embryo that she and Alex had saved whenever she is carrying out the girl disease treatment. He went to Kansas to go to her or him, decided to stand, and you may first started a lifetime which have Izzie in addition to their friends.

Denny Duquette, Jr. [ ]

Whenever Denny is readmitted into the health immediately after suffering cardiac dysrhythmia, Izzie brushed Alex of so she you may usually Denny. Alex sensed threatened by Denny so the guy informed Denny the guy should back just like the he would probably perish off center failure and you may in the event the he made it happen would damage Izzie. When Izzie discovered you to definitely Alex said that it in order to Denny, she faced him and he replied you to she cannot rating involved with customers. She after noticed that she did not have to repay to possess Alex.

But not, Denny endured and so they became closer. He previously a keen LVAD inserted to save him alive for longer therefore he could wait a little for a center, but shortly after learning you to Denny has been around since a great DNR (do not resuscitate) patient, Izzie popped in the possible opportunity to score your a unique heart. After finding that the guy missing a donor heart to help you some one into the the fresh new donor number who was ahead of your because of the 17 moments, she implored your to let the woman cut his LVAD cord so their standing would get worse and then he do go up towards the donor record. Initially, Denny rejected because it would prevent the girl scientific community and he didn’t must discount a middle out of some other mans bust but immediately after Izzie broke off weeping and you may begged him, the guy conformed. Izzie reduce Denny’s LVAD cable and sought the help of the woman fellow interns to keep your alive.

Because the interns struggled to keep Denny alive, Cristina advised him or her that Denny’s doctor, Preston Burke, is actually sample and you may incapable of endure. Once hearing the news, Izzie panicked, totally at a loss. In the course of the chaos, Denny recommended so you can a shocked Izzie. Dr. Miranda Bailey stepped when you look at the into the interns and you can banned them from any surgeries before person who slice the LVAD cable admitted. Meanwhile, Alex anticipate Dr. Erica Hahn to exchange Dr. Burke to your Denny’s cardiovascular system transplant surgery. Dr. Hahn effectively complete Denny’s transplant functions incase Izzie went along to Denny just after their transplant she recognized their marriage offer. Denny passed away away from a stroke quickly afterwards making Izzie devastated and lying next to Denny’s system. Alex transmitted the woman from the bed and shared with her your muscles was not Denny which Denny enjoyed this lady in which he wouldn’t need Izzie to take action so you’re able to by herself.

George O’Malley [ ]

Whenever Izzie discovered that George appreciated Meredith, she encouraged him to inform this lady. Sooner or later, he did however, after their disastrous intimate stumble on together, he went away from home, much to help you Izzie’s disappointment. Despite numerous attempts, George won’t share with Izzie where he is currently life. In the course of time, he went into and often had their brand new spouse, Dr. Callie Torres, more than, much in order to Izzie’s dismay. Izzie managed to get precise in order to George you to she disapproved out of the lady visibility inside the existence due to the fact she noticed Callie a freak. Just after bringing multiple jibes, Callie informed George it actually was as Izzie was at like with him.

After Callie uncovered the fact that she was slightly wealthy and you may is spending most of their debts herself and you will don’t attention undertaking so, a damage George advised Meredith, which advised Izzie. Izzie utilized this informative article when making an excellent snide opinion in the Callie, knowing it would strike a neurological. Infuriated within their indiscretion, Callie kicked George from their hotel room immediately following voicing their viewpoint one to Izzie “had emotions” to own George. Disappointed and you may mislead, George decided to go to Izzie and you can Meredith’s house with a bottle off bourbon and you can after providing drunk, Izzie and George slept with her. The following day, George didn’t come with remember of their intimacy the previous evening and you may did not remember up to he was that have food with Callie along with her dad. George confronted Izzie about this in an effective linen closet in the health and you may after they almost kissed, George remaining when you look at the a rise off shame. Later, Izzie wished to share with Callie but George insisted which getting kept a key.